Interim Adjusted Estimates of Seasonal Influenza Vaccine Effectiveness — United States, February 2013

Early influenza activity during the 2012-13 season enabled estimation of the unadjusted effectiveness of the seasonal influenza vaccine. This report presents updated adjusted estimates based on 2,697 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness (Flu VE) Network during December 3, 2012-January 19, 2013. During this period, overall vaccine effectiveness (VE) (adjusted for age, site, race/ethnicity, self-rated health, and days from illness onset to enrollment) against influenza A and B virus infections associated with medically attended acute respiratory illness was 56%, similar to the earlier interim estimate (62%). VE was estimated as 47% against influenza A (H3N2) virus infections and 67% against B virus infections. When stratified by age group, the point estimates for VE against influenza A (H3N2) and B infections were largely consistent across age groups, with the exception that lower VE against influenza A (H3N2) was observed among adults aged ≥65 years. These adjusted VE estimates indicate that vaccination with the 2012-13 influenza season vaccine reduced the risk for outpatient medical visits resulting from influenza by approximately one half to two thirds for most persons, although VE was lower and not statistically significant among older adults. Antiviral medications should be used as recommended for treatment of suspected influenza in certain patients, including those aged ≥65 years, regardless of their influenza vaccination status.


Interim Adjusted Estimates of Seasonal Influenza Vaccine Effectiveness -United States, February 2013
Early influenza activity during the 2012-13 season (1) enabled estimation of the unadjusted effectiveness of the seasonal influenza vaccine (2). This report presents updated adjusted estimates based on 2,697 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness (Flu VE) Network during December 3, 2012-January 19, 2013. During this period, overall vaccine effectiveness (VE) (adjusted for age, site, race/ethnicity, self-rated health, and days from illness onset to enrollment) against influenza A and B virus infections associated with medically attended acute respiratory illness was 56%, similar to the earlier interim estimate (62%) (2). VE was estimated as 47% against influenza A (H3N2) virus infections and 67% against B virus infections. When stratified by age group, the point estimates for VE against influenza A (H3N2) and B infections were largely consistent across age groups, with the exception that lower VE against influenza A (H3N2) was observed among adults aged ≥65 years. These adjusted VE estimates indicate that vaccination with the 2012-13 influenza season vaccine reduced the risk for outpatient medical visits resulting from influenza by approximately one half to two thirds for most persons, although VE was lower and not statistically significant among older adults. Antiviral medications should be used as recommended for treatment of suspected influenza in certain patients, including those aged ≥65 years, regardless of their influenza vaccination status.
Details of the VE network design, sites, and enrollment procedures have been described previously (2,3). In this report, patients aged ≥6 months seeking outpatient medical care for an acute respiratory illness with cough, within 7 days of illness onset, were enrolled at five study sites.* Consenting participants completed an enrollment interview. Nasal and oropharyngeal swabs were combined and tested using CDC's real-time reverse transcription-polymerase chain reaction (rRT-PCR) protocol. Participants were considered vaccinated if they had received ≥1 dose of any seasonal influenza vaccine ≥14 days before illness onset, according to medical records and registries (at Texas, Washington, and Wisconsin sites) or self-report (at Michigan and Pennsylvania sites).
Of the 2,697 children and adults enrolled during December 3, 2012-January 19, 2013, a total of 1,115 (41%) tested positive for influenza virus by rRT-PCR (Figure). The proportion of patients with influenza differed by study site, sex, age group, race/ethnicity, self-rated health status, and interval from illness onset to enrollment ( Table 1). The proportion vaccinated ranged from 36% to 54% across sites and also differed by sex, age group, race/ethnicity, and self-rated health status (Table 1).
Among the patients with influenza, 32% had been administered the 2012-13 seasonal influenza vaccine, compared with 50% of the influenza-negative controls ( Table 2). For all persons with medically attended acute respiratory illness, the overall VE (adjusted for age group, study site, race/ethnicity, self-rated health status, and days from illness onset to enrollment) against influenza A and B virus infections was 56% (95% confidence interval [CI] = 47%-63%) ( Table 2). Significant VE against influenza A and B viruses was observed among persons in all age groups, except for adults aged ≥65 years.
A total of 366 (33%) of the 1,115 cases had infections caused by influenza B viruses ( Table 1). The adjusted VE estimate for all ages against influenza B was 67% (51%-78%) ( Table 2). The adjusted VE point estimates against influenza B ranged from 64% to 75% across age groups.

Editorial Note
These updated and age-adjusted VE estimates for the 2012-13 influenza vaccine confirm moderate effectiveness in preventing outpatient medical visits caused by circulating influenza viruses, similar to earlier unadjusted estimates in the United States (2) and to recent interim estimates from Canada and Europe (4,5). Overall, influenza vaccination reduced the risk for medical visits resulting from influenza A and B by 56%, from influenza A (H3N2) by 47%, and from influenza B by 67%. The preventive benefits against influenza B were consistent across age groups. The adjusted VE estimates against influenza A (H3N2) viruses also were largely consistent (46%-58%) for persons aged 6 months-64 years, but the estimate was not significant among persons aged ≥65 years. These VE estimates are not final; an increased sample size and adjustment for additional potential confounders (such as chronic medical conditions and functional status) at the end of the season could change these estimates.
Confirmation of the protective benefits of the 2012-13 influenza vaccine among persons aged 6 months-64 years offers further support for the public health benefit of annual seasonal influenza vaccination and supports the expansion of vaccination, particularly among younger age groups. The nonsignificant adjusted VE of 9% against A (H3N2) among persons aged ≥65 years is similar to the estimate in a recent interim report from Europe (6) and reinforces the need for continued advances in influenza vaccines, especially to increase protective benefits for older adults.
One possible explanation for these findings is that some older adults did not mount an effective immune response to the influenza A (H3N2) component of this season's vaccine. Nonetheless, this finding should not discourage future vaccination by persons aged ≥65 years, who are at greater risk for more severe cases and complications from influenza. Influenza vaccines remain the best preventive tool available, and VE is known to vary by virus type/subtype, age group, season, host immunity, and the outcome measured (7). This study observed a VE point estimate against influenza B (67%) that was much higher than the 9% VE estimate against A (H3N2) among older adults, although the precision of estimates was limited by the small sample. Although some previous studies have shown influenza vaccine benefits for older adults, others have failed to demonstrate statistically significant benefits against specific influenza types or subtypes (7). Variability among studies and across seasons and age groups is to be expected and should not change recommendations for annual vaccination. It is also important to note that the VE estimates in this report are limited to the prevention of outpatient medical visits, rather than more severe illness outcomes, such as hospitalization or death. A previous multiseason study found that the influenza vaccine reduced the risk for influenza-associated hospitalizations among older adults by 61% (CI = 18%-82%) (8). A full evaluation of the VE for older adults this season must await consideration of additional data and outcomes. Clinicians should maintain a high index of suspicion for influenza infection among persons with acute respiratory illness while influenza activity is ongoing. Early antiviral treatment can reduce influenza-associated illness severity and complications (9); this season, antiviral treatment of elderly adults is especially important. † CDC recommends initiating  Healthcare (Temple, Texas) (December 9, 2012). † Chi-square testing was used to assess differences between persons with influenza-negative and influenza-positive test results and in the distribution of enrolled patient and illness characteristics and also to assess differences between groups in the percentage vaccinated. § Defined as having received ≥1 dose of vaccine ≥14 days before illness onset. To date, 92% of influenza vaccines administered to participants have been inactivated. A total of 40 participants who received the vaccine ≤13 days before illness onset were excluded from the study sample because of uncertain immunization status. ¶ Enrollees were categorized into one of four mutually exclusive racial/ethnic populations: white, black, other race, and Hispanic. Persons identified as Hispanic might be of any race. Persons identified as white, black, or other race are non-Hispanic. The overall prevalences calculated included data from all racial/ethnic groups, not just the three included in this analysis. ** Two case-patients had coinfections with influenza A and B, making the sum 1,117, or two greater than the total number of influenza positives. † A CDC influenza update for geriatricians and other clinicians caring for persons aged ≥65 years is available at http://www.cdc.gov/flu/professionals/2012-2013guidance-geriatricians.htm. antiviral medications for patients with suspected influenza, regardless of their influenza vaccination status, if they are aged ≥65 years, or hospitalized, or have progressive or complicated illness, or otherwise are at higher risk for complications from influenza. § Antiviral treatment can be initiated empirically, preferably within 48 hours after illness onset, and should not be delayed pending confirmatory diagnostic testing nor be dependent upon tests with limited sensitivity (e.g., negative rapid tests). Among hospitalized patients, treatment should be initiated on admission; several studies suggest effectiveness of antiviral treatment even when initiated ≥48 hours after illness onset (9). The findings in this report are subject to at least four limitations. First, the observational study design has greater potential for confounding and bias relative to randomized clinical trials. Second, although these midseason VE estimates were adjusted for potential confounders identified in previous studies (3), additional factors will be considered in final end-of-season estimates, including health-care-seeking behavior, differences in functional status, and severity of illness, which could influence VE estimates, especially for older adults. Third, no adjustment was made for chronic medical conditions, because of a lack of medical record data for interim analyses; however, VE estimates were adjusted for self-rated health, which is associated with chronic illness and mortality risk (10). Finally, the immunization status of young children (which requires vaccine histories) and vaccine product information (e.g., inactivated compared with live attenuated) also were unavailable for this interim analysis. End-of-season VE estimates could change as additional patient data become available or if circulating viruses or population immunity change over the remainder of the season.
Although imperfect, influenza vaccines remain the best tool currently available for preventing illness from influenza. This report highlights the value of both increasing the use of § Guidance for clinicians on antiviral use is available at http://www.cdc.gov/flu/ professionals/antivirals/summary-clinicians.htm. influenza vaccines, especially among children and young adults, and continuing efforts to develop more effective vaccines and vaccination strategies. Antiviral medications are important for the treatment and control of influenza and should be used as recommended, regardless of patient vaccination status.